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I have just added instruction how to deal with django-syncr and oauth on my blog :
http://fromzerotocodehero.blogspot.com/2010/10/synchronising-django-with-twitter-using.html
Basically you need to update python-twitter to 0.9 version and then do some improvements in __init__
method of syncr.api.tweet . And ye-s, you need to register a new app and get API keys.
Source:stackexchange.com