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Its recommended that You should use virtualenvironments. Install virtualenvwrapper using pip.
pip install virtualenvwrapper
After that open your bashrc and insert relevant lines as mentioned in virtualenvwrapper docs. Then create a virtual environment.
mkvirtualenv myapp
install all python packages including webapp2 to your virtual environment.
pip install webapp2
pip install webob
pip install paste
pip install ipdb
This way, all your packages will be at one single location (/home/username/.virtualenvs/myapp)
And you can import any installed package you want without headaches from relative imports. And for missing termios, you may check SO Post
Source:stackexchange.com