[Answer]-Update permission when user field changes in Django

You can use a post_save Django Signal on the User model, which runs after the User.save() is done, so in your case you want to test for instance.is_active, while you’re you can also revoke the permissions in the signal if the user is set as is_active = False

This is also better than overriding some admin interface, because the post_save will run after the model save, regardless if done from admin panel or elsehwere

https://docs.djangoproject.com/en/1.8/ref/signals/#django.db.models.signals.post_save