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You need to create different instances of django.contrib.admin.sites.AdminSite
Example usage,
# admin.py
from django.contrib.admin.sites import AdminSite
new_admin = AdminSite(name='My New Admin Panel')
new_admin.index_template = "new_admin/index.html"
# urls.py
from myproject.admin import new_admin
(r'^new_admin/(*.)', new_admin.urls)
Source:stackexchange.com