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Can you try using this
AWS_SES_REGION_ENDPOINT = 'email.us-east-1.amazonaws.com'
And not the smtp server setting on AWS’s dashboard?
(You used AWS_SES_REGION_ENDPOINT = 'email-smtp.us-east-1.amazonaws.com'
as mentioned above)
Once you have updated this, you got a new error as updated in your question. This confirms that you now have the correct AWS_SES_REGION_ENDPOINT
setting set.
The reason you are getting this new error is most likely because you are confusing the access keys and giving amazon a wrong set of credentials – see detailed comments here – https://github.com/boto/boto/issues/476#issuecomment-7679158
Follow the solution prescribed in the comment and you should be fine, I think.
Source:stackexchange.com