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Based upon your question, I am not 100% clear what you are looking for. But, assuming you are looking to run some sort of a task every 5 minutes (that will make calls to the DB), then I highly suggest you look at Celery.
It is a robust task schedules, with specific Django integration. Once you get thru the getting started documentation, what you want to look at in particular is called CELERYBEAT_SCHEDULE. This allows you to sort of setup cron like calls.
This has a lot of benefits over cron, and for most use cases I find it to be a better alternative. Scalability is a huge feature for me.
Good luck!
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I think this is likely best accomplished by writing a server-side python script and adding a cronjob
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