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You can "unpack" the dictionary, with:
ModelOne.objects.create(**r)
if r
might contain other fields than fieldone
and fieldtwo
, you will need to filter these out, so:
FIELDS = {'fieldone', 'fieldtwo'}
ModelOne.objects.create(**{k: v for k, v in r.items() if k in FIELDS})
Source:stackexchange.com