[Django]-Queryset in view or in template

If profile.get_somestuff is an expensive operation and you call it multiple times in the template, and yes, you should call that in the view once and pass the result to the template via context.

def view(request):
    ...
    stuff = request.user.profile.get_somestuff()
    return render(request, 'page.html', {'stuff': stuff})

Alternatively, you can use {% with %} tag to create a scope containing the value in its own context:

{% with stuff=user.profile.get_somestuff %}
   ...
   {{ stuff.info }}
   {{ stuff.other_info }}
   ... do some other things with stuff
{% endwith %}

Personally, I would go with the first option because, with the help of django.db.connection.queries, it is relatively easier to monitor db queries you make in the view. Make sure you avoid sending template querysets, lazy expressions etc. as much as possible.

BTW, please note that DEBUG must be set to True for connection.queries to work.