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You can annotate min datetime:
from django.db.models import Min
qs.values('title', 'title__name').annotate(count=Count('book'), min=Min('rx_datetime'))
It will give you something like:
[{'count': 3, 'title': 1, 'title__name': u'OliverTwist', 'min': datetime.datetime(2013,5,1,0,0,0)}]
Source:stackexchange.com