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You can have 2 virtual hosts in your apache configuration.
The first virtual host on (default) – port 80
second one on port 81
In the virtual host, you can specify it this way:
NameVirtualHost *:80
<VirtualHost *.80>
DocumentRoot django_project_1_path
.... other config
WSGIScriptAlias / path_to_wsgi_config_1
</VirtualHost>
NameVirtualHost *:81
<VirtualHost *.81>
DocumentRoot django_project_2_path
.... other config
WSGIScriptAlias / path_to_wsgi_config_2
</VirtualHost>
Source:stackexchange.com