[Answered ]-Is there a simpler way check if the filter i am filtering by is NULL in django?

from django.db.models import Q

MyModel.objects.filter(~Q(grade__isnull=False) & ~Q(subject__exact=''))

edit:

you can take the idea from this here Django Filter Model by Dictionary

or you can make a copy from your data

for i in data.copy():
        if data[i] == "" or data[i] == None:
            data.pop(i)

or

for i in data.copy():
        if not data[i]:
            data.pop(i)

after that MyModel.objects.filter(**data)