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✅
It doesn’t look like there’s any way to use Django’s ORM with SimpleDB at the moment, unless you want to write all the code yourself. I’d suggest interfacing with SimpleDB using normal Python code (which would get called by your views or however you wish to do it).
To do this, use boto. It’s mature, stable and well-documented — I used it quite successfully in a Django project I recently undertook.
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There is now experimental support using django-norel with the django-simpledb backend.
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Source:stackexchange.com