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It is possible indeed.
Using javascript, catch the form submit event.
In the function, serialize the form (exemple using jquery : https://api.jquery.com/serialize/), or get the field values using selectors.
Craft your ajax request, then send it.
And on view side, don’t render a template, use jsonresponse instead : https://docs.djangoproject.com/en/1.9/ref/request-response/#jsonresponse-objects
Source:stackexchange.com