[Fixed]-Effectively communicating between two Django applications on two servers (Multitenancy)

You could use different settings files, let’s say settings_client_1.py and settings_client_2.py, import common settings from a common settings.py file to keep it DRY. Then add respective database settings.

Do the same with wsgi files, create one for each settings. Say, wsgi_c1.py and wsgi_c2.py

Then, in your web server direct the requests for client1.djangoapp.com to wsgi_c1.py and client2.djangoapp.com to wsgi_c2.py