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From the docs for version 1.4:
Support for mod_python has been deprecated, and will be removed in
Django 1.5. If you are configuring a new deployment, you are strongly
encouraged to consider using mod_wsgi or any of the other supported
servers.
For version 1.5, the option is removed and instead you get this warning at the deployment documentation:
Chapter 12 of the Django Book (second edition) discusses deployment
and especially scaling in more detail. However, note that this edition
was written against Django version 1.1 and has not been updated since
mod_python was first deprecated, then completely removed in Django
1.5.
You are encouraged to use mod_wsgi instead. The documentation provides comprehensive guidance on how to deploy with wsgi.