[Answered ]-Django, mod_wsgi, Apache: Internal server error

The mod_wsgi.so is compiled for a specific Python version. You can get this problem if you don’t have that version installed or otherwise force it to use a different Python version, which cannot be done.

Work out what version of Python mod_wsgi.so is compiled for.

http://code.google.com/p/modwsgi/wiki/CheckingYourInstallation#Python_Shared_Library
http://code.google.com/p/modwsgi/wiki/CheckingYourInstallation#Python_Installation_In_Use

So first thing to do is work out what mod_wsgi.so is compiled against.

The web server is out of file descriptors. Use ulimit -n in the httpd initscript to increase the number of file descriptors allowed.