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django-moderation looks interesting, I haven’t used it. There’s not a lot of activity in the project, but it’s active. I think it will suit the use-case you have in mind. I considered django-guardian recently for a project and rejected it in favour of extending tastypie’s authorizations. I think my use case was a bit different, I needed to maintain constraints on foreign key relationships that were hard to express with django-guardian. If you only intend to allow or reject read/write permissions and don’t need to validate anything beyond rudimentary data points, it will do a good job (in that case, use Django’s model validators).
In general: Django has a wide assortment of easily included apps. in general: if you can solve it with pip install, do so.