[Django]-Creating a single connection that persists for multiple view method calls in Django?

Boto has built-in connection pooling and relies on HTTP Keep-Alive feature. So you should be ok.

Source: https://groups.google.com/d/msg/boto-users/O2cae4Rnsps/b8O53OakoSoJ

A related StackOverflow question: Boto connect_xxx method and connection pools