[Answer]-Choosing a web framework for a 3rd party twitter app

First of all, you should understand that tornado will downgrade your application on heavy views. Django is better for apps with thousands of queries on page, cause chaos will be less with blocking model in this case.

Second, yes, switching to tornado + mongodb can improve your application, because you will have to rethink your storage architecture.

Problem here is in storage, not in tools. Try to find how to reduce queries in views, maybe by making heavier calculations in background.