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On an Amazon EC2 setup, I found AWS’s Elastic Load Balancer to be pretty cool (apart from only supporting a single IP address per ELB instance).
The front-end Django boxes just needed their database settings altering to point to a separate database (ie, given the database box’s IP, which was an internal IP in terms of our EC2 ecosystem) and, once the database box was made to listen on that IP and the appropriate port, we were ready to rock.
Source:stackexchange.com