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Why mod_wsgi may crash covered in the FAQ for mod_wsgi.
In particular, you likely are using a C extension module which hasn’t been written correctly to work in Python sub interpreters and so it crashes.
As explained in issues list for mod_wsgi, presuming that it is the only WSGI application running in that mod_wsgi daemon process, force it to run in the main interpreter, using:
WSGIApplicationGroup %{GLOBAL}
Source:stackexchange.com