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Python Eggs are module files that are contained within zip files. The Python Egg Cache is the directory where Python extracts them so it can run them. Currently you are trying to extract them to /.python-eggs but you don’t have write access to either that directory, or to / if it doesn’t exist.
You have two options, you can either create /.python-eggs and make it world writable (or at least writable by the user Apache is running as), or you can set PYTHON_EGG_CACHE (using the WSGIPythonEggs directive) to a directory where you do have write access.
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# Avoid [Errno 13] Permission denied: '/var/www/.python-eggs' messages
import os
os.environ['PYTHON_EGG_CACHE'] = '/tmp'
Source:stackexchange.com