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Use a virtual environment as documented in:
http://code.google.com/p/modwsgi/wiki/VirtualEnvironments
Also see:
http://code.google.com/p/modwsgi/wiki/ConfigurationDirectives#WSGIPythonPath
and the python-path option of:
http://code.google.com/p/modwsgi/wiki/ConfigurationDirectives#WSGIDaemonProcess
Which of the latter you might use depends on how you are running mod_wsgi.
So, lots of documentation available.
Source:stackexchange.com