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There are two major downsides I see right off the bat:
- No minification and perfomance issues: The code that gets delivered will be huge instead of just a small bundle. Also you’ll have things like babel, eslint and hot reloading running all the time in the background when they’re not needed.
- Deployment must happen on a Node.JS server, while when you bundle it pretty much any server can deploy the bundle, as those are only html, css and javascript files.
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Source:stackexchange.com